Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 279 Reviews
8.1
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1 g
<1%**
Milk Thistle Extract (Silybum marianum)(Fruit/Seeds) (Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
†
Turmeric (Curcuma longa) (Root)
700 mg
†
Top Medical Research Studies
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
8
Silymarin showed enhanced liver protection
We explored how different forms of silymarin, derived from milk thistle seeds, affect liver health in older hens. In a study with 70 hens, various treatments were given over 12 weeks, including control groups.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
Most Useful Reviews
9
Improved health
546 people found this helpful
To support my hardworking liver, this herbal remedy is fantastic! After my operation, I experienced pain in the right side, but silymarin was prescribed. I initially took one capsule before meals, then increased to two, and my health has since improved, with my face regaining colour and no pain in my side. This mixture of milk thistle and curcumin gently detoxifies the body while enhancing liver function. For optimal results, consult a nutritionist before using.
7.5
Better digestion
524 people found this helpful
This remedy alleviates bitterness in my mouth due to gallbladder issues and has improved my liver function, as confirmed by tests. It’s essential to take this as a course. I find it beneficial to take two capsules at night or up to three before meals.
9
Essential liver drug
203 people found this helpful
I genuinely appreciate this product for its liver health benefits. I recommend taking it in courses, following breaks. I include it in every meal; milk thistle is a boon for the liver.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
9
Silymarin improves liver health in mice
We investigated how silymarin, along with other natural compounds, affects non-alcoholic fatty liver disease (NAFLD) in mice. Over 16 weeks, mice on a high-fat diet received silymarin supplements, which significantly improved liver health and reduced fat buildup.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
9
We investigated the potential of a specially formulated version of Silybum marianum, known as nano-SM, to combat liver damage caused by a compound called 17α-ethinylestradiol (EE).
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
8
Silybum marianum aids liver health
We conducted a randomized, double-blind trial to explore the impact of a Silybum marianum (SM) and alpha-lipoic acid (ALA) formulation, combined with a Mediterranean diet, on liver health in those with metabolic dysfunction-associated steatosis.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
User Reviews
USERS' SCORE
Good
Based on 279 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved health
546 people found this helpful
To support my hardworking liver, this herbal remedy is fantastic! After my operation, I experienced pain in the right side, but silymarin was prescribed. I initially took one capsule before meals, then increased to two, and my health has since improved, with my face regaining colour and no pain in my side. This mixture of milk thistle and curcumin gently detoxifies the body while enhancing liver function. For optimal results, consult a nutritionist before using.
7.5
Better digestion
524 people found this helpful
This remedy alleviates bitterness in my mouth due to gallbladder issues and has improved my liver function, as confirmed by tests. It’s essential to take this as a course. I find it beneficial to take two capsules at night or up to three before meals.
9
Essential liver drug
203 people found this helpful
I genuinely appreciate this product for its liver health benefits. I recommend taking it in courses, following breaks. I include it in every meal; milk thistle is a boon for the liver.
9
Medicinal benefits
126 people found this helpful
Many cultures revere milk thistle as a powerful medicinal plant for liver diseases, including cirrhosis and jaundice. It’s effective for various health issues, including liver disease treatment, and helps restore cell membranes, enhancing their protection. I take it twice a year to maintain liver health.
9
Diminished spots
100 people found this helpful
This is the best supplement I've taken for my liver and bile health. I've noticed a reduction in red spots on my body, and it’s currently my favourite remedy for liver disease, with a reasonable price.
Frequently Asked Questions
9
Pain relief achieved
40 people found this helpful
After illness requiring antibiotics, I started taking milk thistle to support my liver. Following two months of use, right side pain vanished. I’ll continue taking it to maintain liver health and highly recommend it. Please check for gallstones beforehand.
9
Body detoxification
27 people found this helpful
I'm thrilled with the clean formulation of this milk thistle supplement. It effectively detoxifies my body and improves skin quality. After a week, I noticed a reduction in heaviness around my liver and morning bitterness.
9
Essential liver drug
203 people found this helpful
I genuinely appreciate this product for its liver health benefits. I recommend taking it in courses, following breaks. I include it in every meal; milk thistle is a boon for the liver.
9
Improved health
546 people found this helpful
To support my hardworking liver, this herbal remedy is fantastic! After my operation, I experienced pain in the right side, but silymarin was prescribed. I initially took one capsule before meals, then increased to two, and my health has since improved, with my face regaining colour and no pain in my side. This mixture of milk thistle and curcumin gently detoxifies the body while enhancing liver function. For optimal results, consult a nutritionist before using.
7.5
Better digestion
524 people found this helpful
This remedy alleviates bitterness in my mouth due to gallbladder issues and has improved my liver function, as confirmed by tests. It’s essential to take this as a course. I find it beneficial to take two capsules at night or up to three before meals.
9
Fatigue alleviation
22 people found this helpful
For years I suffered from fatigue related to liver disease. After taking silymarin, my energy levels improved dramatically, enabling me to manage household tasks and feel brighter overall. I am committed to continuing this supplement.
10
Detoxifies effectively
17 people found this helpful
Great product! This supplement excellently detoxifies the liver, kidneys, and relieves stomach issues. I sleep well now and feel a complete relief from my body’s discomforts.
9
Reduces liver bitterness
41 people found this helpful
This supplement significantly improves liver health. After being prescribed it due to bitterness caused by previous antibiotics, I noticed an improvement after the course. A friend had similar success after drinking excessively. I take one capsule three times a day with meals. Ensure no gallstones are present prior to use.
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
8
We explored the role of silymarin, a compound from milk thistle, as an antioxidant treatment for chronic liver diseases like hepatitis and cirrhosis. Through a thorough review of clinical studies, we found that silymarin shows promise for protecting the liver and may help improve liver function in patients with these conditions.
However, while the results are hopeful, more research is necessary to determine the best dosage, long-term safety, and potential interactions with other medications. This review highlights silymarin's potential and sets the stage for future research on its clinical application.
However, while the results are hopeful, more research is necessary to determine the best dosage, long-term safety, and potential interactions with other medications. This review highlights silymarin's potential and sets the stage for future research on its clinical application.
7
We systematically reviewed 29 randomized clinical trials to explore the impact of silymarin, derived from milk thistle, on liver enzyme levels. While many studies showed promising reductions in liver enzymes, some reported no significant changes or even increases.
About 65.5% of the studies indicated that silymarin could be beneficial, especially for those with non-alcoholic fatty liver disease. However, results varied based on patient conditions and dosage, highlighting the need for further research on optimal use.
About 65.5% of the studies indicated that silymarin could be beneficial, especially for those with non-alcoholic fatty liver disease. However, results varied based on patient conditions and dosage, highlighting the need for further research on optimal use.
References
- Koeberle SC, Thürmer M, Su F, Werner M, Grander J, et al. Silybin A from reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids. Theranostics. 2025;15:2006. doi:10.7150/thno.99562
- Cano Contreras AD, Del Rocío Francisco M, Vargas Basurto JL, Gonzalez-Gomez KD, Amieva-Balmori M, et al. Effect of alpha-lipoic acid and supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis. World J Hepatol. 2025;17:101704. doi:10.4254/wjh.v17.i1.101704
- Shaker MK, Hassany M, Eysa B, Adel A, Zidan A, et al. The activity of a herbal medicinal product of Phyllanthus niruri and Silybum marianum powdered extracts (Heptex®) in patients with apparent risk factors for nonalcoholic steatohepatitis: a phase II, multicentered, randomized, double-blind, placebo-controlled clinical trial. BMC Complement Med Ther. 2025;25:8. doi:10.1186/s12906-024-04692-y
- Selc M, Macova R, Babelova A. Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders. Drug Des Devel Ther. 2024;18:4629. doi:10.2147/DDDT.S483140
- Faryadi S, Sheikhahmadi A, Farhadi A, Nourbakhsh H. Evaluating the therapeutic effect of different forms of silymarin on liver status and expression of some genes involved in fat metabolism, antioxidants and anti-inflammatory in older laying hens. Vet Med Sci. 2024;10:e70025. doi:10.1002/vms3.70025
- Dhande D, Dhok A, Anjankar A, Nagpure S. Silymarin as an Antioxidant Therapy in Chronic Liver Diseases: A Comprehensive Review. Cureus. 2024;16:e67083. doi:10.7759/cureus.67083
- Li BY, Xi Y, Liu YP, Wang D, Wang C, et al. Effects of Silybum marianum, Pueraria lobate, combined with Salvia miltiorrhiza tablets on non-alcoholic fatty liver disease in adults: A triple-blind, randomized, placebo-controlled clinical trial. Clin Nutr ESPEN. 2024;63:2. doi:10.1016/j.clnesp.2024.06.003
- Jaffar HM, Al-Asmari F, Khan FA, Rahim MA, Zongo E. Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases-A comprehensive narrative review. Food Sci Nutr. 2024;12:3097. doi:10.1002/fsn3.4010
- Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520
- Wang X, Jin Y, Di C, Zeng Y, Zhou Y, et al. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024;16. doi:10.3390/nu16081169
- Salem MB, Mohammed DM, Hammam OA, Elzallat M. Mitigation of intrahepatic cholestasis induced by 17α-ethinylestradiol via nanoformulation of Silybum marianum L. BMC Complement Med Ther. 2024;24:51. doi:10.1186/s12906-024-04351-2
- Singla RK, Singh D, Verma R, Kaushik D, Echeverría J, et al. Fermented formulation of Silybum marianum seeds: Optimization, heavy metal analysis, and hepatoprotective assessment. Phytomedicine. 2024;124:155286. doi:10.1016/j.phymed.2023.155286
- Calderon Martinez E, Herrera D, Mogan S, Hameed Z, Jangda AA, et al. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review. Cureus. 2023;15:e47608. doi:10.7759/cureus.47608
- Ma X, Yu X, Li R, Cui J, Yu H, et al. Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. J Ethnopharmacol. 2024;319:117238. doi:10.1016/j.jep.2023.117238
- Talebi A, Soltani R, Khorvash F, Jouabadi SM. The Effectiveness of Silymarin in the Prevention of Anti-tuberculosis Drug-induced Hepatotoxicity: A Randomized Controlled Clinical Trial. Int J Prev Med. 2023;14:48. doi:10.4103/ijpvm.ijpvm_81_22
- Ghodousi M, Karbasforooshan H, Arabi L, Elyasi S. Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. Eur J Clin Pharmacol. 2023;79:15. doi:10.1007/s00228-022-03434-8
